Title: !Residency
Tags: Pharmacology::Agitation Psychiatry::Agitation
On every note of this deck, unless a note says otherwise:
reference: Wilson, M. P. The Psychopharmacology of Agitation: Consensus Statement of the American Association for Emergency Psychiatry Project BETA Psychopharmacology Workgroup (2012)

generic: Risperidone PO
trade: Risperdal^®
initial dose: 2 mg
tmax: 1 hr
repeat: 2 hr
maximum daily dose: 6 mg

generic: Olanzapine PO
trade: Zyprexa^®
initial dose: 5–10 mg
tmax: 6 hr
repeat: 2 hr
maximum daily dose: 20 mg

generic: Haloperidol PO
trade: Haldol^®
initial dose: 5 mg
tmax: 30–60 min
repeat: 15 min
maximum daily dose: 20 mg
extra: Likely to cause higher incidence of extrapyramidal side effects than other recommended drugs

generic: Lorazepam PO, IM
trade: Ativan^®
initial dose: 2 mg
tmax: 20–30 min
repeat: 2 hr
maximum daily dose: 12 mg

generic: Ziprasidone IM
trade: Geodon^®
initial dose: 10–20 mg
tmax: 15 min
repeat: 10 mg q2 hr
20 mg q4 hr
maximum daily dose: 40 mg

generic: Olanzapine IM
trade: Zyprexa^®
initial dose: 5–10 mg
tmax: 15–45 min
repeat: 20 min
maximum daily dose: 30 mg

generic: Aripiprazole IM
trade: Abilify^®
initial dose: 9.75 mg
tmax: 1 hr
repeat: 2 hr
maximum daily dose: 30 mg

generic: Haloperidol IM
trade: Haldol^®
initial dose: 5 mg
tmax: 30–60 min
repeat: 15 min
maximum daily dose: 20 mg
extra: Likely to cause higher incidence of extrapyramidal side effects than other recommended drugs

generic: Haloperidol IV
trade: Haldol^®
initial dose: 2–5 mg
tmax: Immediate
repeat: 4 hr
maximum daily dose: 10 mg
extra: Administering haloperidol intravenously increases risk of QT prolongation.
Avoid if possible, especially in patients w/ borderline QT or taking other medication that can prolong QT.
If given IV, limit dose and provide cardiac monitoring.